Sacubitril/valsartan (LCZ696)

Appearance: White to off white powder;
This product is easily soluble in methanol; Almost insoluble in water or acetonitrile;
Specific rotation: -40.0 °~-42.0 ° (methanol);
Chloride: not exceeding 0.1%;
Regarding substances: The maximum single impurity shall not exceed 0.1%; The total magazine shall not exceed 1.0%;
Moisture content: should be 4.0% to 5.9%;
Heavy metals: not exceeding 10ppm;
Content: should be between 97.0% and 102.0%.

Mechanism of action:
By simultaneously blocking angiotensin II receptors (inhibiting overactivation of the RAAS system) and inhibiting enkephalinase degradation (enhancing the protective effect of the natriuretic peptide system), dual regulation of the neuroendocrine system is achieved. This mechanism breaks through the traditional single target drug treatment mode and is considered an important breakthrough in the field of heart failure treatment in the past decade.