(5α)-Androst-2-en-17-one
Appearance: White to off white powder;
Melting point: 104-106 ° C;
Specific optical rotation:+142 ° -+152 ° (c=1, CHCl3)
Dry weight loss: not exceeding 0.10%;
Content: not less than 98.0%.
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(5α)-Androsta-2,16-dien-17-yl acetate
Appearance: White to off white powder;
Specific optical rotation:+80 ° to+92 (c=1, CHCl3)
Dry weight loss: not exceeding 0.5%
Burning residue: not exceeding 0.1%
Content: not less than 98.0%. -
3-Amino-1-adamantanol
Appearance: White crystalline powder;
Solubility: soluble in organic solvents, insoluble in water;
Moisture content: not exceeding 0.5%;
Residue: not exceeding 0.5%;
Chromatographic purity: not less than 99.0%.It is mainly used as an intermediate for the synthesis of adamantane derivatives such as vidaliptin (CAS 274901-16-5) and for the treatment of type 2 diabetes.
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3-hydroxyadamantane-1-carboxylic acid
Appearance: Off white solid;
Solubility: soluble in DMSO (small amount) and methanol (small amount);
Melting point: 203 ° C
Related substances: Single impurities shall not exceed 0.1%; The total impurities shall not exceed 0.50%;
Content: not less than 99.0%.Storage conditions: Sealed Indry, Room Temperature.
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Abemaciclib
CAS No. : 1231929-97-7 Cat. No. : A209941 Formula : C27H32F2N8 Purity : 99% M.W : 506.59 g/mol -
Abemaciclib intermediate
CAS NO.：1231930-42-9
Appearance: Grey white powder;
Dry weight loss: not exceeding 1.0%;
Burning residue: not exceeding 0.5%;
Heavy metals: not exceeding 20ppm;
Content: not less than 99.0%. -
Abemaciclib intermediate
CAS NO.：1231930-33-8
Appearance: White to gray solid;
Dry weight loss: not exceeding 0.5%;
Burning residue: not exceeding 0.5%;
Content: not less than 99.0%. -
Abemaciclib intermediate
Appearance: Powder ranging from off white to off white in color;
Moisture content: not exceeding 0.5%;
Burning residue: not exceeding 0.2%;
Chromatographic purity: not less than 99.0%. -
Abemaciclib mesylate
Appearance: Off white to pale yellow powder
Regarding substances: The maximum single impurity shall not exceed 0.1%; The total magazine shall not exceed 1.0%;
Palladium residue: not exceeding 10ppm;
Dry weight loss: not exceeding 1.0%;
Burning residue: not exceeding 0.5%;
Heavy metals: not exceeding 20ppm;
Methanesulfonic acid content: 12.5~15.5%;
Content: not less than 99.0%. -
Abiraterone
Appearance: Off white powder；
Related substances: Single impurities shall not exceed 0.15%; The total impurities shall not exceed 1.0%;
Dry weight loss: not exceeding 4%；
Content: not less than 99.0%. -
Abiraterone Acetate
Appearance: White or off white powder;
Solubility: This product is easily soluble in dichloromethane; Dissolve in N, N-dimethylformamide or methanol; Slightly soluble in acetonitrile; Almost insoluble or insoluble in water, 0.1mol/L hydrochloric acid solution, and 0.1mol/L sodium hydroxide solution.
Melting point: should be 143~147 ℃
Specific rotation: should be -47 º to -52 º
Moisture content: not exceeding 0.25%;
Burning residue: not exceeding 0.2%;
Heavy metals: not exceeding 20ppm;
Related substances: Single impurities shall not exceed 0.1%; The total impurities shall not exceed 0.5%;
Palladium: not exceeding 10ppm
Content: should be between 98.0% and 102.0% (based on dry product).Abiraterone acetate (trade name ZYTIGA) is a CYP17 inhibitor that blocks androgen production in testicular, adrenal, and prostate cancer tissues by inhibiting the key enzyme 17 α – hydroxylase/C17,20-lyase involved in androgen synthesis. This drug needs to be used in combination with prednisone and is suitable for treating metastatic castration resistant prostate cancer that has previously received chemotherapy containing docetaxel. The standard dose is 1000mg orally on an empty stomach per day, and patients with liver function impairment need to adjust the dose.
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AHU-377 hemicalcium salt
Appearance: White or off white powder;
This product is easily soluble in methanol; Almost insoluble in water or acetonitrile;
Specific rotation: from -16 º to -22 º;
Calcium: should be 4.0%~5.2%;
Regarding substances: The maximum impurity of an unknown individual shall not exceed 0.1%; The total magazine shall not exceed 1.0%;
Enantiomer: not exceeding 0.1%;
Moisture content: not exceeding 8.0%;
Content: should be between 97.0% and 102.0%.
