Trelagliptin Succinate

Appearance: Off white powder
Melting point: should be 180-185 ℃
Specific rotation: should be between 15 ° and 19 °
Acidity pH: should be 4.0~5.5
Chloride: not exceeding 0.02%
Moisture content: not exceeding 0.5%
Burning residue: not exceeding 0.1%
Heavy metals: not exceeding 20 parts per million
Related substances: Single impurities shall not exceed 0.1%; The total impurities shall not exceed 1.0%;
Enantiomer: not exceeding 0.5%
Succinic acid: should be 24.1% to 25.6%
Sulfate: not exceeding 0.02%
Fluorine content: should be 3.6% to 4.2%
Content: not less than 98.5%.

Trelagliptin is a weekly dipeptidyl peptidase IV (DPP-4) inhibitor that controls blood glucose levels by selectively and persistently inhibiting DPP-4. DPP-4 is an enzyme that can inactivate intestinal insulinotropic proteins (glucagon like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP)), both of which play important roles in blood glucose regulation. Inhibiting DPP-4 can increase blood glucose level dependent insulin secretion, thereby controlling blood glucose levels.