Appearance: This product is a white crystalline powder; Odorless, bitter taste, followed by a sense of numbness. This product is highly soluble in water, soluble in ethanol or chloroform, slightly soluble in acetone, and minimally soluble in ether or benzene. Melting point: The melting point of this product is 167-171 ℃. Regarding substances: a single impurity shall not exceed 0.5%, and the sum of all impurities shall not exceed 1.0%. Dry weight loss: not exceeding 0.5%. Burning residue: not exceeding 0.1%. Content: not less than 99.0%.
Appearance: white or off white crystalline powder; When encountering light, it darkens. This product is slightly soluble in methanol, extremely soluble in acetone, and almost insoluble in water or chloroform; Easy to dissolve in glacial acetic acid. Melting point: The melting point of this product is 160-165 ℃, and it decomposes simultaneously during melting. Clarity and color of acidic solution: The solution should be clear and colorless. Regarding substances: a single impurity shall not exceed 0.3%, and the sum of all impurities shall not exceed 1.0%. Dry weight loss: not exceeding 0.5%. Burning residue: not exceeding 0.1%. Heavy metals: not exceeding 10 parts per million. Content: not less than 98.0%.
Appearance: This product is a yellow powder or crystalline powder, odorless. This product is slightly soluble in N, N-dimethylformamide and almost insoluble in water, ethanol, or ether. Acidity: The pH value should be between 5.5 and 7.0. Dissolved substances in ethanol: residual residue should not exceed 0.5%. 5-Nitrofurfural diacetate: not exceeding 1.0%. Dry weight loss: not exceeding 0.5%. Burning residue: not exceeding 0.2% Heavy metals: not exceeding 20 parts per million. Content: should be between 97.0% and 103.0%.
Appearance: This product is a white or off white crystalline powder; Odorless, almost tasteless. This product is soluble in acetone, slightly soluble in ethanol, and insoluble in water. Regarding substances: a single impurity shall not exceed 0.2%, and the sum of all impurities shall not exceed 1.0%. Dry weight loss: not exceeding 0.5%. Burning residue: not exceeding 0.1%. Heavy metals: not exceeding 20 parts per million. Content: not less than 99.0%.
Pharmacological action Mabofloxacin is a new type of fluoroquinolone antibacterial drug that inhibits bacterial growth by suppressing DNA transcription enzymes. It has antibacterial effects on Gram negative bacteria, Gram positive bacteria, and mycoplasma. Mabofloxacin can be absorbed well through oral and injection administration, with low toxicity and side effects.
Appearance: This product is a colorless to pale yellow liquid. Density: approximately 1.243 g/mL~1.3 ± 0.1 g/cm ³. Moisture content: not exceeding 1.0%. Regarding substances: maximum single impurity ≤ 0.2%, total impurity ≤ 1.0%. Content: not less than 98.0%.
Appearance: White crystalline powder； Solubility: Slightly soluble in water, slightly soluble in ethanol. Related substances: The sum of peak areas of each impurity shall not exceed the main peak area of the reference solution (1.0%). Dry weight loss: not exceeding 0.5%； Burning residue: not exceeding 0.1%； Heavy metals: not exceeding 20ppm； Content: not less than 98.5%；
Pharmacological effects:
This product is a novel non anesthetic analgesic with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized ortho methyldiphenhydramine. So it does not have the characteristics of nonsteroidal anti-inflammatory drugs, nor is it an opioid receptor agonist. Effective for moderate to severe pain, intramuscular injection of 20mg of this product is equivalent to the effect of 12mg of morphine. The respiratory inhibitory effect is relatively mild. Has no inhibitory effect on the circulatory system. Lack of tolerance and dependence. Acute toxicity LD50 (mg/kg): Mice, oral administration 66.6; Abdominal cavity 28.7; Vein 21.9. Rats, orally administered 178; Intramuscular injection 56.9.
Appearance: White or off white crystalline powder; Solubility: This product is easily soluble in methanol, ethanol, acetone, glacial acetic acid, and dilute ethanol, soluble in chloroform, slightly soluble in water, and almost insoluble in ether. Melting point: should be 88.5~93.5 ℃; Acidity: The pH value should be 5.5~7.0; Sulfate: not exceeding 0.01%; Moisture content: not exceeding 0.5%; Burning residue: not exceeding 0.1%; Heavy metals: not exceeding 20 parts per million; Related substances: Single impurities shall not exceed 0.1%; The total impurities shall not exceed 0.20%; Content: should be between 99.0% and 101.0%.
Indications: Suitable for the treatment of coronary heart disease and angina pectoris. Effective for exertional, spontaneous, post infarction, or mixed angina pectoris. For patients with angina pectoris accompanied by atrial fibrillation and cardiac enlargement, and for patients who need to use other anti angina drugs with caution.
Appearance: This product is a crystalline powder ranging from off white to light yellow in color; Solubility: It should be slightly soluble in N, N-dimethylformamide and minimally soluble in water or ethanol; Easy to dissolve in acetic acid, hydrochloric acid or sodium hydroxide solution; Melting point: 218~224 ° C; Clarity of the solution: Compared with the turbidity standard solution No. 2, it should not be more concentrated. Regarding substances: Impurity A should not exceed 0.2%, individual impurities should not exceed 0.1%, and total impurities should not exceed 0.5%; Dry weight loss: not exceeding 1.0%; Burning residue: not exceeding 0.1%; Heavy metals: not exceeding 15ppm; Content: should be 98.5-102.0%.
