Tadalafil
Appearance：White or almost white powder.
Solubility：Practically insoluble in water, freely soluble in dimethyl sulfoxide, slightly soluble in methylene chloride.
Specific optical rotation：+ 78.0 to + 84.0 (dried substance).
Unspecified impurities≤ 0.10%
Total≤ 0.30%
Loss on drying：Maximum 0.5 percent
Sulfated ash：Maximum 0.1 percent
Assay：98.5 to 102.0% of the stated amount.
Tadalafil is a selective reversible inhibitor of cyclic guanosine monophosphate (cGMP) – specific phosphodiesterase 5 (PDE5). When sexual stimulation leads to local release of nitric oxide, PDE5 is inhibited by tadalafil, causing an increase in cGMP levels in the penile sponge, which leads to smooth muscle relaxation and blood flow into the penile tissue, resulting in erection; If there is no sexual stimulation, the drug may not be able to exert its effect.
Indications: Treatment for erectile dysfunction (ED). Treat the symptoms and signs of erectile dysfunction (ED) combined with benign prostatic hyperplasia (BPH).
Description
English Name：Tadalafil
Chemical Name：(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1′,2′:1,6] pyrido[3,4b] indole1,4(6H,7H)-dione；(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino [1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione；(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Molecular Formula：C22H19N3O4
Molecular Weight：389.40
CAS NO.：171596-29-5
Additional information
| color | Green |
|---|
Reviews
There are no reviews yet.