Palbociclib
Appearance: Yellow solid
Related substances: less than 0.5%, single impurity less than 0.1%
Dry weight loss: not exceeding 0.5%
Ash content: not exceeding 0.1%
Heavy metals: not exceeding 20ppm
Palladium content: not exceeding 10ppm
Content: 98~102%
Biological activity：Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib is a highly specific inhibitor of cyclindependent kinase 4 (Cdk4) (IC50, 0.011 μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.
Description
English Name：palbociclib
Chemical Name：6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2yl]amino} pyrido[2,3-d]pyrimidin-7(8H)-one；6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one；6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one；PD332991；PD0332991.
Molecular formula：C24H29N7O2
Molecular weight：447.53
CAS NO.：571190-30-2
LogP：0.99
Additional information
| color | Gray |
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