Nefopam Hydrochloride

Appearance: White crystalline powder；
Solubility: Slightly soluble in water, slightly soluble in ethanol.
Related substances: The sum of peak areas of each impurity shall not exceed the main peak area of the reference solution (1.0%).
Dry weight loss: not exceeding 0.5%；
Burning residue: not exceeding 0.1%；
Heavy metals: not exceeding 20ppm；
Content: not less than 98.5%；

Pharmacological effects:

This product is a novel non anesthetic analgesic with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized ortho methyldiphenhydramine. So it does not have the characteristics of nonsteroidal anti-inflammatory drugs, nor is it an opioid receptor agonist. Effective for moderate to severe pain, intramuscular injection of 20mg of this product is equivalent to the effect of 12mg of morphine. The respiratory inhibitory effect is relatively mild. Has no inhibitory effect on the circulatory system. Lack of tolerance and dependence. Acute toxicity LD50 (mg/kg): Mice, oral administration 66.6; Abdominal cavity 28.7; Vein 21.9. Rats, orally administered 178; Intramuscular injection 56.9.